At least five Palestinians have been killed in an Israeli airstrike on a building within the Nasser Hospital complex in Khan Younis, southern Gaza, according to the Hamas-run Civil Defence agency. The strike, which occurred early on Thursday, also left twenty others injured, a civil defence spokesman told the BBC.

Eyewitnesses reported that a single missile, fired from a warplane that briefly flew over the area, struck a building housing the hospital's surgical wards and intensive care units. A surgeon is reported to be among those killed. Videos shared by activists showed thick smoke inside the building and extensive destruction on the second floor, where medical equipment and beds were scattered by the blast.

The director of Nasser Medical Complex said the building was hit in a vertical strike, causing extensive damage to the intensive care and surgical departments for both men and women. There has been no immediate response from the Israeli military, and the BBC has contacted the Israel Defense Forces for comment.

Earlier, civil defence spokesperson Mahmoud Basal told news agency AFP that six people had been killed. The BBC is prevented by Israel from reporting independently from inside the Gaza Strip and is unable to verify details of the incident.

Recovery work is carried out by the Civil Defence in Gaza, which operates under the Hamas-run interior ministry. Its efforts have been supported by the International Committee of the Red Cross (ICRC).

Local activists circulated claims that the strike may have targeted a senior Hamas security figure who was hiding inside the building. Israel often accuses Hamas, which continues to retain its weapons and maintain security control over the Gaza Strip, of using hospitals for military purposes. Hamas denies the allegations.

Nasser Hospital, the largest in southern Gaza, was hit by a double Israeli strike in August 2025, which killed at least 20 people, including journalists and health workers.

Israeli strikes on Gaza have continued despite a ceasefire agreement in October last year. More than 1,600 people have been killed since then, according to Gaza's Hamas-run health ministry, whose figures are considered reliable by the UN. Israel and Hamas have accused each other of violating the ceasefire.

The humanitarian crisis in Gaza has also worsened from recent heavy rains that reportedly flooded tens of thousands of tents that were housing displaced families.

The Gaza war was triggered by the Hamas-led attack on southern Israel on 7 October 2023, when about 1,200 people were killed and 251 others were taken hostage. Since then, more than 74,645 people have been killed in Gaza, the health ministry says.